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The HPV-positive cells, particularly SCC47, showed significant elevations in glycolytic intermediates, nucleotide synthesis, nicotinamide metabolism, and antioxidant demand, reflective of their rapid proliferation and increased oxidative stress

After paraffin embedding, the tissue samples were cut into 7 m sections and processed according to our previous work [16]

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Erastin, in conjunction with SLC7A5 and the SLC7A5/SLC3A2 complex, also downregulates the expression of SLC3A2 and SLC7A11, thereby influencing the occurrence of ferroptosis [12, 74, 75]